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Cell Reports Physical Science,103573 Volume 7, Issue 10 (2026)
Cell-generated forces recapitulate geometry-defined deformation modes in auxetic and non-auxetic micro-architected scaffolds
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Architected scaffolds encode deformation behavior through geometry, enabling auxetic contraction or conventional expansion under applied loading. While these deformation modes are routinely characterized by passive mechanical testing, it remains unclear whether they persist under endogenous, spatially distributed cellular forces. Here, we report the use of "auxetic" and "non-auxetic" elastic, as well as mechanically "stiff" micro-architected scaffolds fabricated by multiphoton lithography to decouple Poisson's ratio from elastic modulus while preserving geometry and porosity. Using neural stem cells as a model system, we show that cell-generated loading produces deformation patterns over time that correspond to those observed under uniaxial compression. Despite fundamentally different loading conditions, transverse deformation remains governed by unit-cell topology, indicating that the geometry-encoded deformation behavior is recapitulated under active cellular loading. This proof-of-concept study supports the predictive value of conventional mechanical characterization for architected biomaterials and provides a framework for investigating architecture-dependent cell-material interactions relevant to tissue engineering and regenerative medicine.
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ACS Appl. Electron. Mater. (2026) 8 (19): 8565–8574
High Energy-Storage Density in Ferroelectric La:HfO2-Based Thin-Film Capacitors
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Ferroelectric and antiferroelectric hafnium and zirconium oxides have attracted considerable attention for the development of next-generation energy-storage capacitors owing to their high energy-storage density (ESD), high power density, moderately high efficiency (eta), and scalability down to the ultrathin limit. Most research on dielectric energy-storage capacitors focuses on antiferroelectric hafnium oxide- and zirconium oxide-based capacitors, while ferroelectric hafnium oxide-based capacitors have been less extensively investigated. This work highlights the enhancement of the energy-storage characteristics of epitaxial ferroelectric orthorhombic lanthanum-doped hafnium oxide-based two-dimensional capacitors by introducing a thin dielectric amorphous alumina capping layer. It is revealed that the inclusion of a dielectric layer influences both the ESD and eta of the fabricated capacitors due to the increased depolarization effect resulting from the presence of the alumina layer. The best balance between ESD and eta is achieved through the insertion of a 2.3 nm-thick alumina layer, providing an ultra-high ESD of 142 J/cm3, with an eta of 69% for an electric field of 7.7 MV/cm. Additionally, the capacitor displays an ESD greater than 120 J/cm3 after 106 cycles and a stable performance up to 120 degrees C. Therefore, this work foresees the potential of ferroelectric epitaxial hafnium oxide-based capacitors in energy-storage technologies.
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ACS Omega (2026) 11 (38): 57830–57844
Fluorescent Biofunctionalized Silver and Gold Nanoparticles: Bright Tools for Bioimaging Applications
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The aim of this work is to evaluate different nanostructured systems based on noble metal nanoparticles suitable for drug delivery and release related to the treatment of multiple sclerosis. To this end, four different systems are thoroughly characterized from a chemical-physical and structural perspective and, then, from a biological perspective. Gold and silver nanoparticles were synthesized and stabilized with different biocompatible ligands, including poly(ethylene glycol), citrate, and cysteine, to modulate their colloidal stability and surface reactivity. UV-Vis spectroscopy revealed characteristic plasmonic absorption bands at about 400 nm for silver and nearly 550 nm for gold nanoparticles. Morphological analyses, performed by Transmission Electron Microscopy, and colloidal stability, studied by Dynamic Light Scattering, highlighted differences in size distribution and polydispersity among the systems. The nanoparticles were subsequently functionalized with fluorescein isothiocyanate, a fluorescent dye, to enable their detection and tracking within cells using an accessible analytical technique appropriate for the study of immune cells, such as flow cytometry. Nanoparticle surface properties were thoroughly investigated by means of Fourier-transform infrared, synchrotron radiation-induced X-ray photoelectron, and near edge X-ray absorption fine structure spectroscopies. Flow cytometry analyses demonstrated efficient nanoparticle-cell interaction with peripheral blood mononuclear cells, and a cell viability assay performed with the improved system highlighted the potential for applications in drug delivery and bioimaging.
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Deliverables view all
WP2 - MGT2 - Pilot scheme for the management of a distributed research infrastructure offering harmonised, interoperable and integrated services
D2.9 - Schemes for a sustainable technical and scientific long-term management
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The Integrated Distributed Research Infrastructure for Nanoscience (IDRIN) has been conceived as a coordinated and interoperable operational model for a distributed research infrastructure bringing together the facilities and services offered by the NEP consortium under a common coordinated framework. The NFFA-Europe IDRIN encompasses a broad ensemble of access providers, including both beneficiaries and Third Parties providing access against Payment (TPaP), whose complementary scientific and technological capabilities collectively form a single and unique European Research Infrastructure (RI) for the science of matter and advanced materials at the nanoscale, with upscale to micro analysis and technology. While maintaining the distributed nature of its constituent facilities, the IDRIN is designed to operate as a single integrated RI. Its operational model combines geographically distributed installations with central coordination mechanisms and local operational nodes, enabling harmonised access procedures, coordinated service delivery, and effective interoperability among providers. Through this approach, users can access via a Single Entry Point (SEP) a broad portfolio of techniques, instruments and expertise through a common framework, independently of the location of the resources required to perform their research. The coordinated operation of IDRIN relies on several dedicated components, each addressing a specific aspect of the infrastructure management. Scientific quality is ensured through the Access Review Panel (ARP), an independent external peer-review body responsible for evaluating the scientific merit of user proposals. Technical coordination is ensured by the Technical Liaison Network (TLNet), a distributed network composed of a central coordinating node and local nodes at provider sites, assessing technical feasibility, supporting users, and coordinating the implementation of optimised work plans across co-located and distributed facilities. The user-oriented dimension of the infrastructure is supported by the User Office Network (UONet) that coordinates the activities of local User Offices, aiming at the provision of harmonised administrative and logistical services throughout the access lifecycle. Through common procedures and shared service standards, UONet supports users in matters such as travel and subsistence reimbursement, logistics, legal and insurance aspects, while contributing to the integration of administrative information across the infrastructure. A further fundamental component of IDRIN is the data management framework, which supports the implementation of FAIR data principles and promotes advanced data stewardship practices across all infrastructure activities. The data management platform provides an integrated environment linking scientific datasets, metadata and access-related information, enabling the production, storage and exploitation of FAIR research data while supporting monitoring, reporting and future socio-economic analyses of the infrastructure usage. Together, these coordination components provide the scientific, technical, operational and datamanagement foundations required to operate the IDRIN as a coherent distributed infrastructure. To support the development of sustainable schemes for the long-term technical and scientific management of the IDRIN, the coordinators of the main operational components were invited to assess the strengths and weaknesses of the current operational model and explain their view on the needs for its further evolution. The analysis presented in this deliverable is based on their contributions and on the common themes emerging across the different coordination areas.
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WP2 - MGT2 - Pilot scheme for the management of a distributed research infrastructure offering harmonised, interoperable and integrated services
D2.8 - Second call for additional providers
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According to the Grant Agreement, in the lifetime of NFFA-Europe Pilot the Transnational Access offer must enlarge to meet (i) the qualitative needs of users that could be better met with new specialized providers, or (ii) quantitative needs resulting in oversubscription of the current capacity. To this aim, two calls for additional access providers were foreseen at M24 and M40, respectively. This report describes the rationale that led to the text of the second call for additional access providers, i.e. from the evaluation of the needs – mainly based on the analysis provided in the deliverable D2.7 “Second balance of access provision” - to the search for alternative solutions to widen and strengthen the current offer.
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WP14 - JA4 - A safe-by-design platform for nanomaterials
D14.4 - Integration and characterization of the space correlation functionality on the complete setup
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This report presents an experimental workflow designed to perform correlative measurements as part of the NEP-NFFA project, using silicon nitride (Si3N4) membranes equipped with platinum (Pt) markers. These membranes were developed through a collaboration between DESY NanoLab and ESRF-ID21. DESY NanoLab was responsible for the Pt deposition on the Si3N4 membranes, while ESRF-ID21 carried out the correlative measurements. The purpose of the Pt markers on the membranes is to act as fiducial points that help to precisely locate specific regions or points of interest (ROI/POI) with micrometric or nanometric accuracy. This is essential to analyze the same point of the sample using different techniques, and to collect complementary data for a better understanding of the sample. The proposed workflow involves complementary techniques such as optical microscopy, scanning electron microscopy (SEM), and synchrotron-based techniques like micro X-ray fluorescence (µXRF) performed at the nano-X-ray microscope (nano-SXM) at beamline ID21 of the Softhis report describes the initial design of the membranes with the markers, as well as the optimized version, based on results obtained during the first tests with nano-SXM. In addition, it shows how the Pt markers enable accurate correlation through the web-based graphical interface Daiquiri, linking the morphological information from optical microscopy with the chemical information obtained from µXRF. The technical feasibility of this approach has been confirmed, showing that the process is reproducible and potentially applicable to similar studies. This is possible due to the standardized Pt deposition process and the use of nano-SXM for sample localization and data acquisition.
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Transnational Access Statistics
31 calls for access
1176 proposals submitted
61% rate of acceptance
30% with Large Scale Facilities
13% with theory
12% with industry
~3 average users per proposal
66 countries applying
3653 lab sessions