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ACS Omega (2026) 11 (38): 57830–57844
Fluorescent Biofunctionalized Silver and Gold Nanoparticles: Bright Tools for Bioimaging Applications
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The aim of this work is to evaluate different nanostructured systems based on noble metal nanoparticles suitable for drug delivery and release related to the treatment of multiple sclerosis. To this end, four different systems are thoroughly characterized from a chemical-physical and structural perspective and, then, from a biological perspective. Gold and silver nanoparticles were synthesized and stabilized with different biocompatible ligands, including poly(ethylene glycol), citrate, and cysteine, to modulate their colloidal stability and surface reactivity. UV-Vis spectroscopy revealed characteristic plasmonic absorption bands at about 400 nm for silver and nearly 550 nm for gold nanoparticles. Morphological analyses, performed by Transmission Electron Microscopy, and colloidal stability, studied by Dynamic Light Scattering, highlighted differences in size distribution and polydispersity among the systems. The nanoparticles were subsequently functionalized with fluorescein isothiocyanate, a fluorescent dye, to enable their detection and tracking within cells using an accessible analytical technique appropriate for the study of immune cells, such as flow cytometry. Nanoparticle surface properties were thoroughly investigated by means of Fourier-transform infrared, synchrotron radiation-induced X-ray photoelectron, and near edge X-ray absorption fine structure spectroscopies. Flow cytometry analyses demonstrated efficient nanoparticle-cell interaction with peripheral blood mononuclear cells, and a cell viability assay performed with the improved system highlighted the potential for applications in drug delivery and bioimaging.
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Materials Today, 103451, Volume 100, Part A
Sputter-resistant aluminium oxide layer enables robust perovskite tandem solar cells
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Protective buffer layers are a key strategy to facilitate the sputter deposition of transparent front electrodes in semi-transparent perovskite and highly efficient perovskite tandem solar cells. Here, we explore a thin aluminium oxide (AlOx) layer, deposited through atomic layer deposition (ALD), as a buffer layer between the established C(60)electron transport layer and sputtered indium tin oxide (ITO) contact in a "p-i-n" (inverted) device architecture. By using multimodal spectroscopic methods, we compare AlO(x)to the more widely employed SnOx. Although ALD is known as a conformal process, we find that the growth of SnOx(<20 nm) on the C(60)layer frequently results in pinholes, whereas similar to 3-5 nm-thin layers of AlO(x)allow for a more homogeneous coverage. The presence of in-gap states revealed in the wide-bandgap alumina buffer layer enables efficient charge extraction. Under low-power magnetron sputtering conditions, a 3 nm AlO(x)buffer layer effectively suppresses sputtering-induced damage, whereas a 1.5 nm AlO(x)layer does not. Devices with 3 nm AlO(x)perform similarly to those with 20 nm SnOx, with power conversion efficiencies exceeding 17% for semi-transparent perovskite and 26% for perovskite/silicon tandem devices. Thus, we conclude the suitability of thin AlO(x)as a sputter-resistant buffer layer offering the advantage of a dense and uniform ALD process, reduced material consumption, and a faster fabrication process for future perovskite tandem and semi-transparent devices.
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Advanced Functional Materials (2026): e77949
Exchange‐Coupled Two‐Dimensional MOFs
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In two-dimensional metal-organic frameworks (2D MOFs), the orientation of the magnetic response is generally assumed to be set by local coordination and lattice symmetry. Here we show that, in an extended two-dimensional coordination network, a remanent molecular magnetic response can instead be imposed by the underlying ferromagnetic substrate. Using element-specific X-ray magnetic circular dichroism, we investigate Fe- and Ni-tetracyanobenzene (TCNB) networks on graphene/Co and demonstrate graphene-mediated ferromagnetic coupling between the molecular layer and the cobalt film. Unlike previous studies on isolated molecules and dense molecular layers, this work extends substrate-mediated interface magnetism to an electronically connected metal-organic framework. By tuning the cobalt thickness across its spin-reorientation transition, we control the orientation of the remanent Fe-TCNB response, which changes from predominantly out-of-plane to in-plane without altering the framework chemistry or structure. Whereas Ni-TCNB shows a field-polarized but non-remanent response, Fe-TCNB exhibits a remanent substrate-coupled component that persists up to room temperature. These results establish substrate engineering as a route to stabilizing and orienting molecular magnetization in two-dimensional metal-organic frameworks.
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Deliverables view all
WP2 - MGT2 - Pilot scheme for the management of a distributed research infrastructure offering harmonised, interoperable and integrated services
D2.9 - Schemes for a sustainable technical and scientific long-term management
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The Integrated Distributed Research Infrastructure for Nanoscience (IDRIN) has been conceived as a coordinated and interoperable operational model for a distributed research infrastructure bringing together the facilities and services offered by the NEP consortium under a common coordinated framework. The NFFA-Europe IDRIN encompasses a broad ensemble of access providers, including both beneficiaries and Third Parties providing access against Payment (TPaP), whose complementary scientific and technological capabilities collectively form a single and unique European Research Infrastructure (RI) for the science of matter and advanced materials at the nanoscale, with upscale to micro analysis and technology. While maintaining the distributed nature of its constituent facilities, the IDRIN is designed to operate as a single integrated RI. Its operational model combines geographically distributed installations with central coordination mechanisms and local operational nodes, enabling harmonised access procedures, coordinated service delivery, and effective interoperability among providers. Through this approach, users can access via a Single Entry Point (SEP) a broad portfolio of techniques, instruments and expertise through a common framework, independently of the location of the resources required to perform their research. The coordinated operation of IDRIN relies on several dedicated components, each addressing a specific aspect of the infrastructure management. Scientific quality is ensured through the Access Review Panel (ARP), an independent external peer-review body responsible for evaluating the scientific merit of user proposals. Technical coordination is ensured by the Technical Liaison Network (TLNet), a distributed network composed of a central coordinating node and local nodes at provider sites, assessing technical feasibility, supporting users, and coordinating the implementation of optimised work plans across co-located and distributed facilities. The user-oriented dimension of the infrastructure is supported by the User Office Network (UONet) that coordinates the activities of local User Offices, aiming at the provision of harmonised administrative and logistical services throughout the access lifecycle. Through common procedures and shared service standards, UONet supports users in matters such as travel and subsistence reimbursement, logistics, legal and insurance aspects, while contributing to the integration of administrative information across the infrastructure. A further fundamental component of IDRIN is the data management framework, which supports the implementation of FAIR data principles and promotes advanced data stewardship practices across all infrastructure activities. The data management platform provides an integrated environment linking scientific datasets, metadata and access-related information, enabling the production, storage and exploitation of FAIR research data while supporting monitoring, reporting and future socio-economic analyses of the infrastructure usage. Together, these coordination components provide the scientific, technical, operational and datamanagement foundations required to operate the IDRIN as a coherent distributed infrastructure. To support the development of sustainable schemes for the long-term technical and scientific management of the IDRIN, the coordinators of the main operational components were invited to assess the strengths and weaknesses of the current operational model and explain their view on the needs for its further evolution. The analysis presented in this deliverable is based on their contributions and on the common themes emerging across the different coordination areas.
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WP2 - MGT2 - Pilot scheme for the management of a distributed research infrastructure offering harmonised, interoperable and integrated services
D2.8 - Second call for additional providers
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According to the Grant Agreement, in the lifetime of NFFA-Europe Pilot the Transnational Access offer must enlarge to meet (i) the qualitative needs of users that could be better met with new specialized providers, or (ii) quantitative needs resulting in oversubscription of the current capacity. To this aim, two calls for additional access providers were foreseen at M24 and M40, respectively. This report describes the rationale that led to the text of the second call for additional access providers, i.e. from the evaluation of the needs – mainly based on the analysis provided in the deliverable D2.7 “Second balance of access provision” - to the search for alternative solutions to widen and strengthen the current offer.
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WP14 - JA4 - A safe-by-design platform for nanomaterials
D14.4 - Integration and characterization of the space correlation functionality on the complete setup
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This report presents an experimental workflow designed to perform correlative measurements as part of the NEP-NFFA project, using silicon nitride (Si3N4) membranes equipped with platinum (Pt) markers. These membranes were developed through a collaboration between DESY NanoLab and ESRF-ID21. DESY NanoLab was responsible for the Pt deposition on the Si3N4 membranes, while ESRF-ID21 carried out the correlative measurements. The purpose of the Pt markers on the membranes is to act as fiducial points that help to precisely locate specific regions or points of interest (ROI/POI) with micrometric or nanometric accuracy. This is essential to analyze the same point of the sample using different techniques, and to collect complementary data for a better understanding of the sample. The proposed workflow involves complementary techniques such as optical microscopy, scanning electron microscopy (SEM), and synchrotron-based techniques like micro X-ray fluorescence (µXRF) performed at the nano-X-ray microscope (nano-SXM) at beamline ID21 of the Softhis report describes the initial design of the membranes with the markers, as well as the optimized version, based on results obtained during the first tests with nano-SXM. In addition, it shows how the Pt markers enable accurate correlation through the web-based graphical interface Daiquiri, linking the morphological information from optical microscopy with the chemical information obtained from µXRF. The technical feasibility of this approach has been confirmed, showing that the process is reproducible and potentially applicable to similar studies. This is possible due to the standardized Pt deposition process and the use of nano-SXM for sample localization and data acquisition.
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Transnational Access Statistics
31 calls for access
1176 proposals submitted
61% rate of acceptance
30% with Large Scale Facilities
13% with theory
12% with industry
~3 average users per proposal
66 countries applying
3653 lab sessions