Plasma Surface Nanotexturing is a surface nanoengineering technique that is mostly appropriate for polymeric surfaces. The technique allows simultaneous etching and inhibitor deposition on the polymer surface, resulting in roughness (texture) formation from sub 100 to several hundred nm high. The roughness in combination with the chemical modification from the plasma results in full control of the wetting and adhesion properties of the surface. This in turn also results in fouling or biomolecule binding control. The technique can be applied to polymer plates, foils, rolls, coatings and also on open microfluidic devices. The technique may allow blanket surface modification, or local modification if the surface is exposed through a stencil mask.